Generating novel plant genetic variation via genome editing to escape the breeding lottery

Abstract Plant breeding relies on the presence of genetic variation, which is generated by a random process mutagenesis that acts existing gene pools. This variation then recombined into new forms at frequencies impacted local euchromatin and heterochromatin environment. The result lottery where plant breeders face increasingly low odds generating “winning” genotype. Genome editing tools enable targeted manipulation genome, providing means to increase enhancing chances for success. Editing can be applied in way, known improves performance directly brought lines interest through either deletion or insertion. empowers approaches are traditionally difficult such as novel domestication introgression wild accessions germplasm pool. Furthermore, broader editing-mediated recombination enhancement bring ways creation toolbox. Continued development application genome will needed aid meeting critical global crop improvement needs.